Business –

MSA: Pittsburgh, PA
Best places ranking: #2 among large metro areas
Population: 2,351,192

Greater Pittsburgh is home to a workforce with hard-won manufacturing skills from the city’s steelmaking past. Need machinists? They’re here — and that’s a draw for small businesses.The region combines that talent pool with a mix of highly educated students from the University of Pittsburgh, Carnegie-Mellon University and Duquesne University. Those institutions helped make Pittsburgh a leader in robotics, healthcare, and artificial intelligence. Locals cite the city’s culture as one of its biggest selling points: There are tight-knit neighborhoods, many built around eastern European communities that prize a strong work ethic.

Most of the city’s small businesses are family-owned concerns that have morphed to serve new markets. Resources like the Institute for Entrepreneurial Excellence help both startups and generations-old companies get the skills they need. Pittsburgh’s location on major North-South and East-West interstates connects companies with distant markets and suppliers.

State taxes aren’t low, and the recession-fueled tax shortfall hurts: The state may have to take over Pittsburgh’s pension system. But small businesses say the local workforce is resilient, and with valuable, transferrable skills.

Native Pittsburghers often stick around to raise their own families. It can be hard to retain outsiders, through — those drawn from elsewhere to Pittsburgh’s world-class educational institutions typically collect their degrees and leave. -Barbara Darrow

MSA: Oklahoma City, OK
Best places ranking: #1 among large metro areas
Population: 1,206,142

Stable and affordable, Oklahoma City is a haven for entrepreneurial risk takers. It boasts the second lowest foreclosure rate among large U.S. metro areas, along with the second lowest median rent. Through the Great Recession this former Dust Bowl capital has been spared many hardships, with a diverse local economy spread across medical research, energy, education and government.Oklahoma City also benefits from a high concentration of deep-pocketed local investors, many of them veterans of the oil and gas industry, who are willing to take a gamble on companies that might spend 10 years bringing a new product to fruition. And the city itself has been a powerful friend to life-science startups, funding the 1996 construction of the Presbyterian Health Foundation Research Park. The complex — 700,000 square feet of space in seven buildings on a 27-acre site — has attracted an influx of innovative biomedical firms.

Oklahoma City has its drawbacks. Among the most tornado-prone cities in America, it has the dubious distinction of getting hit in 1999 by the worst twister on record, with winds topping 320 miles per hour. And forget about entertaining your visiting clients with top-notch sporting events: Oklahoma City has only one professional franchise, the NBA’s Oklahoma City Thunder, which had its first season in 2008 and finished 26th in the league. -Alec Foege